Site Contracts Manager II (Sponsor-Dedicated/ Remote - US only)

About this role

Site Contracts Manager II (Sponsor-Dedicated/ Remote - US only) Syneos Health® is a leading fully-integrated life sciences services organization built to accelerate customer success. We partner with innovators at every point across the drug development and commercialization continuum, helping them navigate complexity, anticipate change and accelerate progress.   Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.   Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.   Discover what your 25,000 future colleagues already know:   Why Syneos Health • We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program. • We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life.  • We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress. 

Job Responsibilities

Site Contracts Manager II (Sponsor-Dedicated) Remote – United States

Are you a clinical contracts professional who thrives on negotiation, stakeholder collaboration, and delivering results in a fast-paced environment? Do you enjoy partnering directly with investigative sites and major academic institutions to develop creative contract and budget solutions that accelerate study startup timelines?

We are seeking a Site Contracts Manager II to support a Sponsor-Dedicated program focused on Pharma and Vaccine clinical trials. This role serves as a key partner in the development, negotiation, and management of site budgets and Clinical Trial Agreements (CTAs), ensuring contracts are executed efficiently while minimizing legal, operational, and financial risk.

This is an excellent opportunity for an experienced site contracts professional who enjoys balancing contract strategy, budget negotiations, relationship management, and operational execution across multiple therapeutic areas, including oncology.

WHAT YOU WILL DO

As a Site Contracts Manager II, you will serve as a subject matter expert for site budgets and contracts, partnering with investigative sites, academic institutions, sponsors, and cross-functional stakeholders to ensure timely execution of agreements that support clinical trial startup and study conduct. Site Budget Development & Negotiation • Develop, review, and negotiate site budgets from sponsor-approved templates.

• Lead end-to-end budget negotiations directly with investigative sites and study teams.

• Evaluate proposed budgets for alignment with sponsor expectations and Fair Market Value (FMV) principles.

• Support budget strategy discussions and provide recommendations to internal stakeholders.

• Manage budget-related escalations and facilitate resolution of negotiation challenges.

• Perform budget due diligence activities when sites do not proceed with the initial offer.

Site Contract Development & Negotiation • Draft, review, negotiate, and finalize Clinical Trial Agreements (CTAs) and associated contract documents.

• Lead negotiations directly with large academic institutions, academic medical centers, and investigative sites.

• Develop detailed contract specifications that support business objectives while minimizing legal, operational, and financial risk.

• Review proposed contract language and determine when legal or business escalations are required.

• Secure necessary approvals for contract language or budget escalations.

• Support timely contract execution while ensuring compliance with sponsor requirements.

Project Leadership & Study Delivery • Independently manage multiple contracting projects simultaneously across various therapeutic areas.

• Prioritize workload and drive deliverables to meet study startup timelines and business objectives.

• Partner with Clinical Operations, Legal, Finance, and Study Start-Up teams throughout the contracting lifecycle.

• Identify and proactively escalate risks, delays, and issues that may impact contract execution timelines.

• Support studies involving complex startup activities and key milestones, including Site Initiation Visits (SIVs).

Compliance & Risk Management • Conduct due diligence reviews, including FMV assessments and site justification evaluations.

• Ensure compliance with sponsor SOPs, policies, work instructions, and applicable regulations.

• Maintain current knowledge of ICH-GCP guidelines, industry regulations, sponsor processes, and emerging technologies.

• Apply sound risk assessment principles during contract review and negotiation activities.  

Systems, Reporting & Operational Excellence • Maintain accurate and timely updates within contract management systems, databases, and departmental trackers.

• Utilize Excel and clinical trial management tools to manage workflow, reporting, and study metrics.

• Ensure documentation remains complete, accurate, and audit-ready.

• Participate in process improvement initiatives designed to enhance efficiency, productivity, and overall quality.

• Contribute ideas and solutions that simplify contracting workflows and reduce operational waste.

Collaboration

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