Director, Translational Medicine Clinical Lead-Immunology

About this role

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world.  We provide an inclusive work environment where each person is considered as an individual.  At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Clinical Development & Research – MD

Job Category: Scientific/Technology

All Job Posting Locations: Cambridge, Massachusetts, United States of America, San Diego, California, United States of America, Spring House, Pennsylvania, United States of America

Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine   About Immunology Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases.   Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine   We are searching for the best talent for a Director, Translational Medicine Clinical Lead, Translational Science & Medicine to be in Spring House, PA, La Jolla, CA or Cambridge, MA.   The Director, Translational Medicine (TM), will be a program and experimental medicine leader in the Immunology Translational Science and Medicine (TSM) function. In this position, the Director, TM, will decisively contribute to accelerating the Immunology pipeline from portfolio entry to Proof-of-Concept (PoC).  The Director, TM, will function as a clinical lead/study responsible physician on early development programs and trials. They will contribute to creating translational plans for programs that are aligned with overall TA strategy and with relevant disease area and/or pathway strategies.    They will be empowered to lead a cross-functional clinical trial team to deliver on the trial’s major execution milestones within governance-approved timeline and budget commitments.  This responsibility extends end to end for clinical trials: from initial protocol design to continued monitoring and problem solving on trial execution to the analysis, interpretation, and communication of study results.  This role will partner with Translational Sciences, and deep engagement with investigators and external experts is expected.  In this leadership role, they will be supported by the senior leaders within the Translational Science and Medicine function, including the relevant disease area leaders (both in clinical development and biomarker science) and a clinical study responsible scientist.  The span of studies in scope are phase 1 (including focused experimental medicine studies) through Proof of Concept. Within TM, the Director will be part of a Translational Medicine Program Lead group which has primary responsibility within TSM for creating and implementing innovative translational plans for portfolio assets.  TSM is a group within the Immunology Therapeutic Area, consisting of a Translational Medicine and Translational Science (TS).  TM has combined expertise in the clinical study of immunologic disease, immunologic pathways, and in early clinical trial design and execution. TS has expertise in biomarker development, disease biology research, and in the application of immunology and data science technologies to support drug   development.  Organizationally, TSM serves as a pivotal bridge between Discovery Research and the later phase Clinical Development group. TSM provides the necessary scientific and clinical expertise to advance an industry-leading pipeline of novel mechanism small molecules and biologic agents to address unmet need in immune-mediated diseases. This position will play a ‘dual role’, contributing both scientific and clinical development expertise to TSM projects.

Responsibilities are as follows: • Design and execute program translational strategies integrating both disease and pathway approaches. • Design and execute early clinical trials through PoC including experimental medicine studies.  • Lead a cross-functional trial team to deliver on study milestones and commitments. • Collaborate with translational science on the development and implementation of clinical biomarker and patient segmentation strategies. • Support experimental medicine studies.  • Support Business Development, including due diligence activities. • Represent TM on early development teams. • Represent TM for project teams when presenting to portfolio, project, and governance meetings. • Lead or participate in cross-functional working groups such as scientific and safety review boards.  • Identify and collaborate with academic translational sites to optimize the translational strate

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