Director, Business Strategy & Operations - Commercialization

About this role

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/ , and follow us on X , LinkedIn and Facebook .

Role Summary :

As Dyne advances toward commercial launch across multiple therapy areas, we are seeking an experienced Business Strategy and Operations leader to play a central role in shaping and executing our transition from late-stage development to a fully integrated commercial company.

The Director, Business Strategy & Operations - Commercialization will play a critical role in enabling the Commercial organization to operate with clarity, alignment, and executional excellence as Dyne advances toward launch. Acting as a senior strategic and operational partner to the Chief Commercial Officer, this leader ensures that commercial priorities are translated into well‑defined, coordinated, and measurable action across the organization.

This role sits at a key intersection of strategy, operations, and cross‑functional leadership, ensuring that commercial perspectives, priorities, and readiness are clearly embedded in key priority projects and initiatives. The role provides strong operational leadership and continuity to establish a world class CCO team, helping translate commercial strategy into coordinated action across the organization. The Director will help establish the systems, processes, and operating rhythm needed to dri ve commercial readiness, support the CCO and Commercial Leadership Team, and ensure the organization remains focused on the highest‑value priorities. They will anticipate needs, connect workstreams, and bring structure and consistency to a rapidly evolving environment.

The ideal candidate brings significant biotech experience, strong strategic and analytical capabilities, and excellent judgment. They are comfortable navigating ambiguity, influencing without authority, and simplifying complexity for senior audiences. This is a high‑impact role with broad visibility across the enterprise, suited for a leader who thrives in a fast‑paced, high‑growth setting and is energized by building and enabling high‑performing teams.

This is a full-time position based in Waltham, MA.

Primary Responsibilities Include:

Strategic & Operational Partnership:

• Partner closely with the CCO to translate commercial strategy and priorities into actionable and measurable plans, ensuring clarity, structure, and consistency across initiatives.

• Promote alignment, communication, and collaboration across Commercial and partner functions to ensure connectivity between strategy and execution.

• Support preparation and coordination for the CCO’s engagement with key external stakeholders, including KOLs, HCPs, patient advocacy groups, strategic partners, and senior leaders, ensuring interactions are strategically aligned and well-coordinated.

Business Operations & Operating Rhythm:

• Establish and manage the operating rhythm for the Commercial organization, including leadership forums, governance processes, decision-focused meetings, and business reviews that drive alignment and accountability.

• Drive operational excellence through OKRs, dashboards, performance tracking, and business review processes, providing transparency on progress, dependencies, risks, and resource needs.

Cross-Functional & Enterprise Initiatives:

• Lead and coordinate high-priority, cross-functional initiatives essential to commercial readiness, serving as the central connector between Commercial and partner functions with clear roles, responsibilities, and timelines.

• Promote effective collaboration across Commercial and enterprise partner functions to remove barriers, accelerate decision-making, and ensure successful execution of key priorities.

Leadership Enablement & Organizational Effectiveness:

• Develop and deliver high-quality executive materials, including Board updates, enterprise presentations, town hall content, and cross-functional communications in partnership with Corporate Affairs.

• Help strengthen Commercial team culture by reinforcing collaboration, accountability, and clear communication as the organization grows and prepares for launch.

• Enable leadership effectiveness through executive communications, stakeholder alignment, and organizational engagement activities that support Commercial readiness and performance.

Education and Skills Requirements:

• 10+ years of progressive experience in biotechnology, pharmaceuticals.

• Bachelor’s degree required; advanced degree (MBA, PharmD, PhD) preferred.

• Life science consulting experience preferred.

• Experience supporting a successful rare disease product launch in a commercial, strategic, or operational leadership capacity is preferred.

• Strong cross-functional leadership experience in high-growth, dynamic environments.

• Exceptional communication, organization, and influencing skills; able to simplify complex topics for senior audiences.

• Highly self-directed and effective in ambiguity; strong judgment, prioritization, and follow-through.

• Demonstrated ability to handle confidential information with discretion and build trusted relationships at all levels.

• Thrives in dynamic, stretching environments with evolving needs.

• Ability to travel as needed; up to 25%

• Leadership Characteristics:

• Calm, confident presence with strong analytical and strategic thinking.

• Collaborative and solutions-oriented, with the ability to influence without for

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