US Commercial AI, Portfolio Lead

About this role

As we accelerate the enterprise AI agenda and scale agentic AI across the Chief Marketing Office, the AIA Organization is seeking a Senior Director Commercial AI Portfolio Lead reporting to the VP of Transformation Lead, AIA. This role serves as the single accountable leader for AI portfolio governance, value realization, and operating excellence across AI Builds to support US Marketing, Field, Market Access & Patient Services.   The role will enable a federated build model that enables approved citizen-developer teams to build agents within a centrally governed operating model led by the Commercial AI team. This leader will manage a team who will set the standards, decision rights, controls, shared registry, and planning routines required to ensure capabilities are sequenced effectively, reused where appropriate, and built in alignment with Legal & Compliance, privacy, responsible AI, security, data, and deployment expectations. This role and supporting team is responsible for partnering closely with the CIO to ensure the seamless connectivity between CIO approaches/standards and Commercial AI builds. The Senior Director and their direct reports will be responsible for architecting and operationalizing use case intake, governance and registry.

Key Responsibilities   Commercial AI Build Standards & Central Governance   • Define the centrally governed build operating model for functional-area teams , including decision rights, intake criteria, approval pathways, documentation expectations, control points, escalation triggers, and handoff requirements in support of Commercial AI builds. and  in line with CIO platform standards

• Ensure all Commercial -area-built agents and AI-enabled workflows adhere to Legal & Compliance, privacy, responsible AI, security, data use, information protection, and model / prompt evaluation standards before deployment. 

• Partner with CIO, Data, Legal, Privacy, Compliance, and Security teams to align build patterns, permissioning, data product usage, API access, telemetry capture, and production deployment requirements. 

Portfolio Strategy & Executive Influence   • Provide strategic guidance for incubation  and exploration use cases across in-scope functions, eliminating redundancy and deduplicating assets across the organization. 

• Serve as senior thought partner to the VP of Transformation Lead and the AIA leadership team on AI portfolio direction, capability gaps, build sequencing, shared dependencies, and incubation / exploration investment trade-offs. 

• Drive cross-functional alignment with the Business, Finance, Legal, Privacy, Compliance, Technology, Data, and Security stakeholders to ensure consistent decision-making, resource optimization, and responsible scaling. 

• Set infrastructure to understand AI direction across Commercial; enabling holistic strategic planning and decision making.

Planning Governance, Shared Registry & Cross-ATC Trade-offs   • Stand up a Commercial governance model and shared AI build registry to sequence dependencies, identify reuse opportunities, manage capacity constraints, and resolve cross-ATC trade-offs. 

• Use the shared registry to maintain visibility into what is being built, by whom, for which business need, using which data products, APIs, permissions, evaluation methods, telemetry, and deployment path. 

• Identify overlaps, conflicts, and platform dependencies early, and drive executive-level decisions that balance speed, business value, compliance standards, user experience, and enterprise reuse. 

AI Governance Council & Platform Assessment   • Lead US Commercial AI Governance as the gold standard adopted enterprise-wide, with clear governance coverage for both centrally built and functionally built agentic AI capabilities. 

• Chair the Commercial AI Council and orchestrate cross-functional decision-making at the executive level. 

• Continuously evolve governance standards in partnership with Legal, Privacy and Compliance to balance speed of execution with risk management. 

• Lead assessments of new AI platform capabilities and features, such as Claude Cowork, evaluating fit, risk, readiness, data implications, and adoption pathway for Commercial use. 

• Partner with Compliance on these assessments to confirm new capabilities meet regulatory, privacy, responsible AI, and security standards before rollout. 

AI-Powered Intake, Reporting Platform & Portfolio Visibility   • Partner with CIO Organization on the end-to-end design and delivery of the AI-powered Intake & Reporting Platform, replacing manual workflows with automated submission, evaluation, prioritization, governance routing, and stakeholder reporting. 

• Integrate the shared AI build registry into intake and reporting workflows to provide real-time, organization-wide visibility into portfolio status, build ownership, value capture, reusable assets, dependencies, standards compliance, and available capabilities. 

• Use the platform to surface investment recommendations, incubation candidates ready for Alpha elevation, reusable patterns, and pattern-of-use signals that inform next-wave Tier 1 capability identification. 

• Design the prioritization framework that evaluates initiatives across business impact, technical feasibility, data readiness, resource requirements, compliance readiness, security posture, reuse potential, and strategic alignment. 

Value Realization   • Define incubation and exploration metrics and value-tracking standards adopted across the portfolio. 

• Define measurement expectations for functional-area-built agents, including value hypotheses, adoption measures, usage telemetry, quality / evaluation outcomes, risk indicators, and deployment readiness. 

• Drive portfolio-level course corrections from performance data, ensuring AI investments compound business value across US Commercial and the CMO. 

AI-First Operating Model & Cross-Functional Leadership   • Embed AI-first operating principles within the function,

Similar jobs

• US Commercial AI, Portfolio Lead — Pfizer · New York City, New York, United States | Collegeville, Pennsylvania, United States
• Vice President, US Commercial AI Product Lead, AIA — Pfizer (Internaljobs) · New York City, New York, United States
• Applied AI Architect, Commercial — Anthropic · San Francisco, CA | New York City, NY
• Sales AI Portfolio Operations Manager — Ouryahoo · United States of America
• Total Portfolio Analytics & Investment AI Strategy Lead — Northwestern Mutual · Milwaukee, WI Corporate
• Growth Product Manager Lead, AI Commercialization — Plaud · San Francisco, CA
• Senior Analyst, Commercial Analytics & AI — Johnson & Johnson · Raritan, New Jersey, United States | Cincinnati, Ohio, United States
• Commercial AI Strategy Director — PwC · NY-New York | MI-Grand Rapids | IN-Indianapolis