Senior Systems Engineer, IT Infrastructure & Cloud Solutions

About this role

Who We Are: Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit  neurocrine.com , and follow the company on  LinkedIn ,  X , Facebook and YouTube . ( *in collaboration with AbbVie )

About the Role: This is a hands-on, automation-driven senior systems security engineering role responsible for planning, implementing, and driving enterprise technology infrastructure security posture and regulatory compliance readiness across Linux, Windows, cloud, on-prem, and hybrid environments. The engineer serves as a senior technical resource for enterprise infrastructure vulnerability management, overseeing the process from initial alert through remediation and closure verification. The role also develops and improves patch automation using scripting, configuration management, and orchestration, while continuously evaluating tools and processes to adapt to changes in the infrastructure and threat landscape. The engineer applies deep systems engineering and enterprise systems administration expertise to plan and execute security patches, and translates Cybersecurity policy requirements into implemented, auditable controls, establishing KPIs to measure and report progress against security risk remediation goals. The engineer also establishes and maintains Standard Operating Procedures (SOPs) and change management controls to ensure infrastructure security changes are consistently documented and traceable. This provides objective evidence for security and access control audits while maintaining continuous organizational audit readiness. This role serves as a key technical resource and liaison between Cybersecurity, IT business partners, Internal Audit, and Compliance/Quality functions, ensuring that security requirements are operationalized consistently and remediation work is tracked to closure with measurable outcomes. _ Your Contributions (include, but are not limited to): Security Automation and Vulnerability Management at Scale • Lead complex infrastructure vulnerability remediation efforts and continuously improve the tools and automation used to detect, remediate, and verify security findings across Linux, Windows, cloud, network, and hybrid infrastructure

• Plan and implement security patches across enterprise Linux and Windows server environments, including patch testing, sequencing, rollback planning, and post patch validation

• Lead and coordinate the enterprise vulnerability remediation program across cloud (AWS/Azure), on prem, and hybrid infrastructure, prioritizing based on risk severity, exploitability, and business impact

• Design and implement a scalable patch management framework across AWS, Azure, and hybrid infrastructure including Linux and Windows servers, network devices, and platform services, reducing reliance on manual, one-off remediation efforts

• Apply enterprise systems administration expertise (OS hardening, configuration management, service dependencies) to assess patch impact and minimize disruption to production systems

• Partner with Cybersecurity to translate vulnerability scan findings and audit action items into clear, actionable remediation plans with committed timelines and owners

• Extend vulnerability management support to the application layer, partnering with Business teams and application owners to identify, prioritize, and drive remediation of application vulnerabilities alongside infrastructure remediation efforts

• Administer and enhance the organization’s automation platforms, including AWS Systems Manager (SSM) Patch Manager, and integrate them with other automation and orchestration tools to scale vulnerability detection, patching, remediation tracking, and closure verification across AWS, Azure, and hybrid environments

• Develop and maintain KPIs and reporting mechanisms (e.g., patch compliance rate, mean time to remediate, aging of open findings, risk trend over time) to measure and communicate progress of security risk remediation efforts to leadership and governance forums

• Coordinate remediation activities across Technology Infrastructure, Network Engineering, Cloud Engineering, and Scientific Systems teams to ensure consistent execution and minimal disruption to operations

• Continuously identify opportunities to shift from reactive, one-off patching toward standardized, repeatable, and automated remediation processes

Change Management, SOPs, and Audit Readiness • Establish and maintain security vulnerability management SOPs, work instructions, and documentation standards for infrastructure security changes to ensure consistent, compliant execution across all systems

• Implement, maintain and monitor controls designed to ensure infrastructure security changes (network, cloud, compute, storage, identity, and security configuration) are documented, approved, and traceable end to end

• Build and maintain a long-term remediation evidence repository (change records, approvals, exceptions, risk acceptance artifacts, testing/validation artifacts, access reviews) that supports ob

Similar jobs

• ML Systems Engineer, Infrastructure & Cloud — Basis Research · New York Office
• Systems Engineer, Infrastructure — Tmhcc · Texas - Houston (Corporate Office)
• Senior IT Systems Engineer — Xai · Palo Alto, California
• Senior IT Systems Engineer — Fullstory · Atlanta
• Senior IT Systems Engineer — Nexhealth · San Francisco, California, United States; Seattle, Washington, United States
• Senior IT Systems Engineer — Garnerhealth · New York City, New York
• Senior IT Systems Engineer — Scoutai · Sunnyvale, CA
• Senior IT Systems Engineer — Intercom · San Francisco, California