Senior Scientist – Process Development

About this role

The Opportunity:

Under limited supervision, develop and implement solutions for customers based on our products and services through close collaboration with customers and other innovation associates/scientists. Identify and develop innovative applications for a range of products to solve specific customer issues by planning and executing hands on studies at internal and customer laboratories. What   We’re   Looking For  

• Ph.D. in Molecular Biology, Biochemistry, Bioengineering, Chemical/Biochemical Engineering, Pharmaceutical Sciences, Biotechnology, or   a related field   (required).  

• Minimum of 5+ years of relevant industry experience in mRNA, RNA, nucleic acid, biologics, or pharmaceutical process development. Doctoral or relevant academic experience may be considered equivalent to industry experience.  

• Strong understanding of mRNA process development, including DNA template generation, in vitro transcription (IVT), enzymatic processing, purification, and analytical characterization.  

• Hands-on experience with nucleic acid process development, molecular biology techniques, and scalable manufacturing processes.  

• Knowledge of process development principles including DOE,   QbD , process characterization, scale-up, risk assessment, and CPP/CQA relationships.  

• Experience troubleshooting complex technical challenges, interpreting multidisciplinary data, and developing data-driven solutions.  

• Excellent technical writing, presentation, project leadership, and cross-functional communication skills.  

Preferred Qualifications  

• End-to-end mRNA development experience from DNA template preparation through purified mRNA and formulation interface.  

• Experience with IVT, capping/polyadenylation, chromatography, TFF/UF-DF, process scale-up, technology transfer, or GMP manufacturing support.  

• Familiarity with high-throughput automation, continuous manufacturing, process intensification, PAT, or advanced manufacturing technologies.  

• Experience with mRNA analytical techniques such as HPLC/UPLC, LC-MS, CE, qPCR/ ddPCR , Bioanalyzer/ TapeStation , sequencing, or impurity analysis.  

• Experience applying DOE,   QbD , JMP, Minitab, Python, R, or related statistical and data-analysis tools.  

• Exposure to GMP/GLP environments, regulatory documentation, method qualification, validation, or technology transfer activities.  

• Experience evaluating emerging technologies, vendors, CDMOs, external collaborations, or technical due diligence opportunities.  

How You Will Thrive and Create an Impact  

Process Development  

• Design, develop, and   optimize   end-to-end mRNA manufacturing processes, including DNA template generation, IVT, enzymatic processing, purification, buffer exchange, and formulation interfaces.  

• Develop robust and scalable workflows to improve mRNA yield, purity, quality, process robustness, and manufacturability.  

• Apply DOE,   QbD , risk assessment, and statistical tools to build process understanding and   establish   relationships between process parameters and product quality attributes.  

• Collaborate with Analytical Development to characterize mRNA identity, integrity, purity, potency-related attributes, and process impurities.  

• Troubleshoot process and product-quality challenges using scientific and data-driven approaches, including root cause analysis and risk mitigation.  

• Author technical reports, development summaries, risk assessments, SOPs, study protocols, and   regulatory-support   documentation.  

• Evaluate and   demonstrate   emerging technologies including synthetic DNA, novel purification approaches, automation, process intensification, and continuous manufacturing concepts.  

Development Support  

• Support process characterization, control strategy development, and implementation of CPPs, CQAs, in-process controls, and process   monitoring   strategies.  

• Collaborate with manufacturing, quality, analytical, formulation, and regulatory teams to ensure successful process transfer and commercial readiness.  

• Participate in deviation investigations, change controls, root cause analyses, and continuous improvement initiatives.  

• Support GMP documentation activities including batch records, SOPs, process transfer packages, and validation-related documentation.  

• Assess external technologies, vendors, CDMOs, and strategic collaboration opportunities through proof-of-concept studies, technical due diligence, and workflow integration assessments.  

• Present technical findings, recommendations, and development strategies to project teams, cross-functional stakeholders, and senior leadership.  

• Mentor junior scientists and contribute to a culture of scientific excellence, innovation, safety, and operational rigor.  

​

Disclaimer: The above statements are intended to describe the general nature and level of work being performed by employees assigned to this classification. They are not intended to be construed as an exhaustive list of all responsibilities, duties and skills required of employees assigned to this position. Avantor is proud to be an equal opportunity employer.

Why Avantor? Dare to go further in your career. Join our global team of 14,000+ associates whose passion for discovery and determination to overcome challenges relentlessly advances life-changing science.   The work we do changes people's lives for the better. It brings new patient treatments and therapies to market, giving a cancer survivor the chance to walk his daughter down the aisle. It enables medical devices that help a little boy hear his mom's voice for the first time. Outcomes such as these create unlimited opportunities for you to contribute your talents, learn new skills and grow your career at Avantor.   We are committed to helping you on this journey through our diverse, equitable and inclusive culture which includes learning experiences to support your career growth and success. At Avantor, dare to go fur

Similar jobs

• Senior Associate Scientist, Process Development — Elanco · Fort Dodge, IA
• Senior Scientist, Process Chemistry — Merck · South San Francisco (Grand Ave), California, United States
• Senior Scientist/Team Leader – Bioprocess Development — Ecolab · King of Prussia, Pennsylvania, United States
• Senior Scientist, Product & Process Technology — Endo · Hobart, NY (Pharma) - USA036
• Senior Scientist, Downstream Process Development — Elanco · Indianapolis, IN
• Scientist, Process Development — Elevatebio · Waltham, Massachusetts, United States
• Principal Scientist, Process Engineering — Newperkinelmer · GSK (Collegeville) - Customer Site PA
• Scientist - Process Development, Upstream — Catalent · Madison, WI