Senior Scientist – Functional Genomics

About this role

Career Category Research Job Description Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist – Functional Genomics

What you will do The Functional Genomics group within Target Discovery and Biology (TD&B) is seeking a highly motivated Senior Scientist to develop and apply innovative genome engineering technologies that accelerate therapeutic target discovery and deepen our understanding of disease biology across multiple therapeutic areas.

In this role, you will have the opportunity to establish and advance innovative functional genomics capabilities that are broadly deployed across discovery programs, enabling target identification, validation, and mechanistic studies. Working in a highly collaborative research environment, you will partner with multidisciplinary teams to translate cutting-edge technologies into impactful biological discoveries that advance the next generation of therapeutics.

We are seeking a creative and technically accomplished molecular biologist with expertise in molecular biology, genome engineering, and functional genomics. Demonstrated expertise in the design, engineering, production, optimization, and characterization of viral vectors—particularly adeno-associated virus (AAV) and lentiviral vectors—is required. Candidates with exceptional molecular biology expertise and a demonstrated ability to rapidly develop viral vector engineering capabilities are also encouraged to apply.

Key Responsibilities: • Develop and implement next-generation viral vector platform and genome engineering technologies to expand functional genomics capabilities and accelerate target discovery. • Design, engineer, produce, optimize, and characterize AAV and lentiviral vectors for genetic perturbation applications, including gene overexpression and CRISPR-based genome engineering (e.g., knockout, activation, and other emerging approaches), in both in vitro and in vivo model systems. • Design and execute innovative molecular biology and functional genomics experiments supporting target discovery, target validation, and mechanistic studies. • Design, execute, analyze, and interpret experimental studies, communicating findings and biological insights to multidisciplinary discovery teams. • Evaluate and implement emerging technologies in genome engineering, viral vector engineering, and functional genomics to enhance discovery capabilities. • Collaborate effectively with scientists across biology, computational biology, chemistry, and therapeutic area teams to solve challenging biological problems.

What we expect of you We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a scientist with these qualifications.

Basic Qualifications: Doctorate degree [and relevant post-doc where applicable] OR Master's degree and 3 years of scientific experience OR Bachelor's degree and 5 years of scientific experience

Preferred Qualifications: • Ph.D. in Molecular Biology, Cell Biology, Genetics, Bioengineering, Virology, or a related discipline with 1–2 years of relevant postdoctoral and/or industry research experience. • Strong background in molecular biology, genome engineering, CRISPR technologies, and functional genomics. • Demonstrated expertise in design, engineering, production, optimization, and characterization of AAV and/or lentiviral vectors is strongly preferred. • Experience applying viral vector technologies to support in vitro and in vivo CRISPR-based genetic perturbation studies. • Expertise in molecular cloning, construct design, and development of genetic tools. • Excellent experimental design, data analysis, troubleshooting, communication, and collaboration skills. • Demonstrated scientific creativity, innovation, and success in a multidisciplinary research environment.

What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan • Stock-based long-term incentives • Award-winning time-off plans • Flexible work models where possible. Refer to the Work Location Type i

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