Senior Scientist

About this role

Job Family : Scientist Travel Required : None Clearance Required : Ability to Obtain Public Trust

What You Will Do:

We are looking for a Senior Scientist to support the operational and research objectives of the National Institute on Aging (NIA) Intramural Research Program by supporting genomic, genetics, single-cell sequencing, and spatial transcriptomics research activities. This is a full-time position located in Baltimore, MD. • Provide on-site scientific expertise, laboratory support, and data analysis support for genomic and genetics experiments conducted by NIA research staff.

• Organize, validate, and process samples for microarray, next-generation sequencing, spatial transcriptomics, and single-cell sequencing experiments.

• Use advanced scientific knowledge and laboratory skills to resolve complex genetics and genomics issues, provide experimental guidance, and conduct pilot studies to develop and improve laboratory techniques.

• Maintain an accurate inventory of samples, reagents, and consumables through tracking systems and databases; obtain vendor quotes and assist with purchasing requests for laboratory supplies, services, and equipment.

• Perform operational troubleshooting, calibration, software updates, and maintenance of specialized laboratory instruments while ensuring compliance with laboratory safety procedures.

• Support the planning, execution, troubleshooting, and analysis of single-cell and spatial transcriptomics experiments utilizing platforms such as Chromium X and CytAssist.

• Acquire, maintain, and support specialized laboratory instrumentation and evaluate emerging technologies, software, and methodologies for potential implementation.

• Design and conduct complex scientific experiments requiring broad knowledge of molecular biology, genomics, transcriptomics, and related scientific principles.

• Provide technical support and scientific guidance to laboratory staff on research projects, experimental design, assay development, and data interpretation.

• Establish, train users on, and help manage Laboratory Information Management Systems (LIMS) and Electronic Laboratory Notebooks (ELN).

• Maintain, calibrate, troubleshoot, and train staff on laboratory instrumentation, equipment, and associated software applications.

• Manage scientific resources, including reagents, frozen cell stocks, biological samples, and research inventories.

• Conduct bioinformatics and statistical analyses and prepare data for abstracts, scientific reports, manuscripts, and presentations.

• Maintain accurate and detailed electronic laboratory notebooks and research documentation.

• Collaborate with Principal Investigators and research staff to prioritize instrument usage and optimize laboratory operations.

• Coordinate with IT personnel regarding software, data management, instrument connectivity, and technology-related issues.

• Prepare technical reports, manuscripts, abstracts, posters, oral presentations, and other scientific communications.

• Present research findings at laboratory meetings, scientific conferences, symposia, and national scientific meetings.

• Support data management and sharing initiatives, including organizing and uploading datasets to repositories such as GEO, SRA, and MassIVE.

• Provide mentoring, training, and technical guidance to fellows, postdoctoral researchers, students, biologists, and junior scientists.

• Support scientific collaborations, grant-related activities, laboratory organization initiatives, and research program development.

• Provide scientific guidance to management and laboratory leadership through literature reviews, technical evaluations, and recommendations for research activities and equipment purchases.

• Incumbent capture, no other candidates were considered due to incumbent candidate identified. They meet the labor category requirements provided by the customer.

What You Will Need:

• Ph.D. in Neuroscience, Biology, or a related scientific field.

• Minimum of EIGHT (8) years of experience in genomics, genetics, molecular biology, and transcriptomics research.

• Hands-on background supporting single-cell sequencing and spatial transcriptomics workflows.

• Skilled in operating, maintaining, and troubleshooting specialized scientific instrumentation.

• Background conducting bioinformatics and statistical analyses of genomic and transcriptomic datasets.

• Proven ability to prepare scientific manuscripts, technical reports, presentations, and publication-quality figures.

• Knowledge of laboratory inventory management, research documentation, and electronic records.

• Proficiency with Microsoft Office Suite.

• Ability to train, mentor, and support researchers and laboratory personnel.

• Ability to maintain detailed electronic laboratory notebooks and research records.

• Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:

• Familiarity with OLINK Explore Protein Biomarker Discovery platforms.

• Knowledge of 10X Genomics single-cell sequencing technologies.

• Strong oral and written communication skills.

• Collaborative approach to working with multidisciplinary research teams.

• Background supporting shared scientific core facilities or advanced research laboratories.

• Ability to implement or administer Laboratory Information Management Systems (LIMS).

• Skilled in managing scientific datasets and submissions to public repositories such as GEO, SRA, and MassIVE.

• Exposure to Data Management and Sharing (DMS) initiatives.

• Record of peer-reviewed publications and scientific presentations.

• Mentoring background with fellows, postdoctoral researchers, students, or junior scientists.

• Ability to evaluate and implement emerging laboratory technologies and research methodologies.

The annual salary ra

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