Senior Director, GTM Strategy & Portfolio Planning

About this role

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on   In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible.    Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.

What You'll Do

The Senior Director, GTM Strategy & Portfolio Planning will own the long-term go-to-market strategy for encaleret (BridgeBio’s oral CaSR negative allosteric modulator for Autosomal Dominant Hypocalcemia Type 1) and shape how BridgeBio prioritizes and sequences investment across its broader endocrine portfolio. This role sits at the center of pre-launch strategy, indication sequencing, and portfolio-level resource planning, translating deep market and competitive insight into a durable multi-year commercial roadmap. The ideal candidate is a systems-level strategic thinker who has led at least one rare disease launch and can move fluidly between long-range portfolio strategy and the field-level realities that make a launch succeed. You will report to the SVP, Sales & Marketing — Endocrinology, and be based in the San Francisco Bay Area with regular in-office collaboration.

Responsibilities

• Own the end-to-end GTM strategy for encaleret — market entry sequencing, positioning, and long-range commercial roadmap — from pre-NDA approval through Year 1+ and beyond

• Lead marketing portfolio planning across BridgeBio’s endocrine pipeline, building the framework used to prioritize investment, sequence launches, and allocate commercial capacity across current and future assets

• Serve as the senior commercial strategist on the encaleret Product Team, embedding market, competitive, and portfolio insight into cross-functional planning with Medical Affairs, Regulatory, Market Access, R&D, and Patient Advocacy

• Partner with Value & Access and Finance to align long-term payer strategy, forecasting, and lifecycle planning with the broader endocrine portfolio roadmap

• Partner closely with the HCP Marketing, Patient Marketing, and KOL Engagement functions to ensure GTM and portfolio strategy translate into coordinated field execution, serving as the strategic through-line across these teams without direct management authority over them

• Build and govern the competitive intelligence, market research, and forecasting infrastructure that informs both encaleret’s launch strategy and portfolio-level decision-making

• Develop and present long-term GTM and portfolio strategy updates to senior leadership and the Board of Directors

Where You'll Work

This is a hybrid, San Francisco Bay Area–based role, with in-office collaboration expected Tuesday through Thursday weekly across our San Francisco and Palo Alto offices, and ~25% travel for key congresses, advisory boards, and field engagement.

Who You Are

• Bachelor’s degree required; MBA or advanced science degree preferred

• 12+ years of commercial biotech or pharmaceutical experience, including 7+ years in marketing, GTM, or portfolio strategy roles

• Rare disease launch and GTM strategy experience required; endocrinology or nephrology experience is a significant differentiator

• Demonstrated experience building portfolio planning frameworks, resource allocation models, or franchise-level prioritization across multiple assets

• Proven ability to lead through influence rather than authority, aligning marketing, medical, access, and R&D stakeholders around a shared strategy in a pre-launch, high-ambiguity environment

• Ability to travel ~25% for key congresses, advisory boards, and field engagement

• You have demonstrated curiosity and adaptability in adopting AI-powered tools and technologies

At BridgeBio, we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio is a multi-state employer, and this salary range may not reflect positions based in other states.

Salary $265,000 — $290,000 USD

As a global company, our comprehensive benefits may vary based on location. We have high expectations for our team members. We make sure those working hard for patients are rewarded and cared for in return.

For Full-Time U.S Based Roles:

Financial & Rewards

• Market-leading compensation

• 401(k) with employer match

• Employee Stock Purchase Program (ESPP)

• Pre-tax commuter benefits (transit and parking)

• Referral bonus for hired candidates

• Subsidized lunch and parking on in-office days

Health & Well-Being

• 100% employer-paid medical, dental, and vision premiums for you and your dependents

• Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA)

• Fertility & family-forming benefits

• Expanded mental health support (therapy and coaching re

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