Senior Associate Scientist, AAV Cell Line Development (Contractor)

About this role

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.

We're seeking a Senior Associate Scientist to join our Synthetic Biology team on a 6 month contract. The ideal candidate will have a proven track record performing AAV and/or lentiviral vector stable producer cell line development in an industry setting. They will be a key contributor to our team, participating in the creation of stable producer cell lines for AAV and/or lentiviral vector therapeutics and research projects to improve our cell line development workflows. They will also work closely with Asimov’s synthetic biology and process development teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering.

About the Role:

- Perform AAV and/or lentiviral vector stable producer cell line development processes including transfection, cloning, characterization, and cell banking using state-of-the-art equipment

- Perform biological assays including ddPCR, ELISA, and flow cytometry

- Support innovation through development of novel workflows and applications

- Support research projects to develop viral vector therapeutics with enhanced quality attributes such as empty/full ratio, potency and/or cell targeting

- Work effectively as part of a cross-functional team in support of a synthetic biology design platform

- Design experiments, analyze data, troubleshoot, and maintain detailed records

- Represent the cell line development function on project teams, making decisions for cell line activities and effectively communicating results, progress and plans

- This is a full-time, 6-month contract position providing maternity leave coverage. While the role is intended to support this temporary need, there may be an opportunity to extend the contract or transition to a permanent position based on business needs.

About You:

- B.S or M.S. in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field

- 5+ years of hands-on experience in AAV and/or lentiviral vector producer cell line development in support of GMP production of cell or gene therapies

- Experience performing transfections, viral transductions, flow cytometry, and quantitative gene expression analyses (ddPCR, qPCR, ELISA) is highly desired

- Experience with viral genome engineering, and/or host cell genome engineering related to virus production or producer cell line technologies is highly desired

- Strong written and verbal communication skills required

We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

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