Scientist (In Vivo), Immunology/Pharmacology

About this role

Join us to build differentiated medicines in immunology

At  AstraZeneca , we are investing in the next wave of  immunology and autoimmune disease  innovation. We are looking for a strong  in vivo scientist  who wants to do more than run studies: someone who can generate robust data, think critically about biology, and help shape programs from  target validation through early development . This role sits within our  Early Respiratory & Immunology  organization and is ideal for a scientist who brings deep hands-on  in vivo pharmacology  expertise, thrives in a collaborative research environment, and is motivated by translating complex immunology into decisions that matter for patients. You will contribute to programs in areas such as  SLE, arthritis, and other immune-mediated diseases , working closely with project teams to answer mechanistic and translational questions with high scientific rigor.

Why this role stands out

This is not a purely executional in vivo role. We are looking for someone who can combine  technical excellence ,  disease insight , and  sound experimental judgment . The successful candidate will have the opportunity to influence study design, interpret data in biological context, and contribute meaningfully to portfolio progression. You will be positioned to: • Own critical in vivo study execution  across disease and mechanistic models in immunology • Generate translationally relevant data  that helps teams make faster, better decisions • Partner cross-functionally  with pharmacology, immunology, translational sciences, and project leadership • Grow into study leadership  and become a go-to expert for in vivo immunology approaches • Contribute to a high-impact portfolio  focused on serious diseases with substantial unmet need

What you will do You will design, execute, and interpret  in vivo studies  that support discovery and early development programs in immunology. You will work with a high degree of independence while collaborating closely with colleagues across functions. Key responsibilities include: • Designing and running in vivo studies  in disease and mechanistic models relevant to autoimmune and inflammatory biology • Administering candidate molecules  and collecting blood, tissue, and other biological samples with strong technical proficiency • Supporting biomarker strategy  through sample collection, assay planning, and data interpretation • Processing tissues and generating downstream data  using approaches such as  flow cytometry, immunofluorescence, multiplex immunoassays, RNA isolation, and qPCR • Evaluating and interpreting primary data  to identify meaningful pharmacology and mechanism-related insights • Preparing clear study summaries and reports  that enable project teams to act on results • Maintaining the highest standards  in  animal welfare, ethics, documentation, data integrity, and study quality • Depending on experience,  leading in vivo study activities  for discovery and early development programs

What we are really looking for We are especially interested in candidates who bring a combination of the following: • Strong hands-on in vivo expertise  with confidence operating independently in a research setting • A solid grounding in immunology and pharmacology , with the ability to connect experimental outcomes to disease biology • Experience generating high-quality samples and data  across both in vivo and ex vivo workflows • Scientific curiosity and critical thinking , not just technical execution • Clear communication skills , including the ability to explain data, caveats, and implications to diverse stakeholders • A collaborative mindset  and the maturity to work productively across disciplines

Essential qualifications • BSc required  in  immunology, pharmacology, biology, or a related discipline + 5 years of experience • MSc preferred , or equivalent depth of hands-on scientific experience + 3 years of experience • Proven experience in  in vivo research  using animal models • Demonstrated capability in  tissue collection and sample processing • Experience with one or more relevant techniques, including  flow cytometry and analysis, immunofluorescent staining, multiplex ELISA or related immunoassay platforms, RNA isolation, and qPCR • Good understanding of  immunology, pharmacology, and physiology • Experience in  data analysis, study documentation, reporting, and archiving • Familiarity with  statistical methods  and quality-focused experimental practice • Strong written and spoken  English communication skills

Highly desirable experience Candidates will stand out if they have experience in one or more of the following areas: • Industry experience  in  biopharma  or  drug discovery • Research in  autoimmune or inflammatory disease , such as  SLE, arthritis, or IBD • Experience with  specialized in vivo techniques  or development/optimization of in vivo models • Use of  translational biomarkers  to bridge preclinical findings to clinical questions • Exposure to working in  matrixed project teams  where data drives portfolio decisions

What success looks like in this role In this position, success means consistently delivering  reliable, decision-enabling data , proactively identifying experimental risks or alternative interpretations, and becoming a trusted scientific contributor within project teams. Over time, you will help strengthen our in vivo capability, elevate experimental quality, and influence how we progress promising immunology programs.

Why AstraZeneca At AstraZeneca, we combine  deep scientific expertise ,  bold ambition , and a shared commitment to patients. In  Respiratory & Immunology , we are building a pipeline designed to do more than treat symptoms: we aim to change the course of disease. You will join a team that values  scientific excellence, collaboration, innovation, and integrity , and you will have the opportunity to do meaningful work in an environment that supports growth.

Apply If you are an in vivo

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