Scientist, ADC Oncology Discovery Biology

About this role

Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients.  Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies.  With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome.  We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets.   We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials.  We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Summary We are seeking an experienced individual with biologics drug discovery expertise to join the Discovery Biology team within the Oncology Thematic Research Center at Bristol-Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, interactive, and creative scientist and with the ability to work across a highly matrixed organization to advance programs from target validation to lead optimization, selection of drug candidate and IND-enabling biology related activities. This individual will be dedicated to designing and executing experimental studies related to the decisional progress of our programs from early stages all the way through IND filling. The candidate will be involved in executing biology bench studies that will advance the understanding of mechanism of action as well as developing several screening funnel assays that will enable compound triaging and identification of potential drug candidate. In addition, the individual will work closely with the informatics and predictive science, translational research, and lead optimization teams to design/execute work related to patient stratification, identification of appropriate in vitro PD markers and assay development/transfer for miniaturization.

Position Responsibilities In the role as a Scientist within Discovery Biology, the ideal candidate: • Uses current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates

• Applies extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships

• Designs and executes molecular and cellular studies.

• Collaborates with rest of biology team members as well as other functional area leads e.g. pharmacology, DMPK, informatics and predictive science.

• Presents data in lab meetings as well as full team project meetings.

• Executes experiments independently, troubleshoot as needed, interpret, and discuss data.

• Utilizes excellent communication and interpersonal skills.

• Communicates via email, meetings, and reports.

• Conducts experimental work independently, with accurate, detailed record-keeping.

• Performs laboratory work related but not limited to tissue culture, qPCR, western blot, multi-parametric flow cytometry, immune cell culture using activation/expansion/exhaustion assays, proliferation and tumor killing assays, 2D/3D co-culture activity assays, ELISA, Luminex, processing of DNA/RNA/protein.

Experience

Basic Qualifications: • Bachelor’s Degree • 5+ years of academic and / or industry experience

Or • Master’s Degree • 3+ years of academic and / or industry experience

Or • Ph.D. or equivalent advanced degree in the Life Sciences • No experience necessary

Preferred Qualifications: • Bachelor’s/Master’s Degree and 1-2 years relevant industry experience.

• Experience in oncology and immuno-oncology biologics drug discovery (antibody-drug-conjugates preferred).

• Proficient with expression modulation tools e.g. CRISPRs, shRNAs, siRNAs.

• Extensive knowledge of flow cytometry, Incucyte and high content imaging platforms

• Experienced in the design, development and optimization of high-throughput cell-based assays for antibody screening and ADC activity

• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.

• Ability to summarize and interpret scientific data in a clear, concise, and accurate manner.

• Excellent oral and written communication skills.  Ability to communicate well with peers and supervisors.

• Strong problem-solving skills and understanding of

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