Research Leader / Senior Scientist (In vivo Pharmacology & Translational Sciences), Cambridge, MA

About this role

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease.

The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery.

Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture.

The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you.

About Iso

Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed.

Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases.

We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design.

Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI.

Your impact

Isomorphic labs are seeking exceptional individuals to join a highly impactful Translational Biology sub-team, within our Translational Sciences team, which specialises in small molecules. We’re hiring at the Research Leader and Senior Scientist levels, and you can apply for either position using the application form below.

These roles are ideal for experienced translational biologists with a skill for designing fit-for-purpose screening cascades to provide robust experimental evidence that our ML-designed medicines will have the desired therapeutic product profiles (TPPs). You will be responsible for establishing and implementing translational strategies, advancing our oncology, immunology and partnership portfolios from early drug discovery through to candidate selection and ultimately to clinical phase work. These are exciting opportunities to work closely with world leading ML and drug discovery experts to develop imaginative new ways to test biological hypotheses, building a deep mechanistic understanding of drug target interactions in disease to drive our projects forward. By overseeing externalized CRO activities, you will close the loop between computational biological insights and real-world laboratory validation. You will have experience of working broadly across drug discovery projects and have the ability to think originally and critically, knowing when to apply innovative ideas, and think with a fresh approach.

What you will do

• Oversee the comprehensive planning, methodology development, fiscal management, and implementation of target-specific in vitro and in vivo pharmacology, PK/PD, and safety assessments throughout our project portfolios.

• Design robust translation strategies explicitly geared toward clinical translation, leveraging datasets and biomarkers to inform patient selection frameworks.

• Play a critical role in defining the most appropriate model paradigm (in vivo, ex vivo patient-derived tissue etc) for each project’s translational package, including developing a biomarker strategy to deliver early clinical proof of concept.

• Work with CROs to design decision-making experiments, and deliver the highest quality biological data to inform the path to the clinic.

• Provide scientific expertise to the ML and computational biology teams, to support the development of world-leading models of biological systems.

• Distill biological data into useful insights and recommendations for project leaders, project team members, and partners.

• Be closely integrated within or lead projects to provide strategic input to deliver project success.

• Analyze and interpret experimental data to deliver high-quality reports that drive go/no-go decisions and support IND regulatory filings.

• Act as a vital bridge between computational prediction and experimental reality, collaborating closely with:

• ML and Data Science Teams: To translate in silico predictions into physical validation protocols and provide clean data loops to train future models, iteratively improving the predictive accuracy of our proprietary drug design platform.

• Discovery Biology and Lead Optimization: To seamlessly transition hits generated by our drug design engine into advanced preclinical characterization and guide SAR-driven design cycles with rapid, reliable preclinical efficacy data.

• DMPK and Toxicology: To align in vivo efficacy with ADME and exposure data, informing safety windows and dose selection.

• Clinical Development and Program Management: To translate preclinical PK/PD hypotheses into first-in-human trial designs, biomarker strategies, and patient inclusion criteria.

Skills and qualifications

Essential:

• Ph.D. in Pharmacology, Immunology, Cancer Biology, Molecular Biology, or a related scientific discipline.

• 8+ years / 5+ years of professional experience in a Translational Sciences role, operating within a biotech, pharma or CRO setting.

• Experience of project leadership / leading biology within small molecule drug discovery programs, ideally from inception to clinical candidate

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