Process Development Sr Scientist

About this role

Career Category Operations Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Process Development Sr Scientist

What you will do Let’s do this. Let’s change the world. In this vital role you will define the favorable quality characteristics of the therapies it produces and optimizes state-of-the-art analytical tools to guide that development. The Pivotal PD organizations focus is developing and commercializing robust manufacturing processes across a wide range of therapeutic modalities, including (but not limited to) monoclonal and bispecific antibodies, bispecific T-cell engagers (“BiTEs”), live oncolytic viruses, and synthetic medicines.

• Identifying and characterizing attributes of therapeutic proteins and synthetic molecules using advanced analytical techniques • Develop and apply novel sample preparation and analytical methods for analysis of therapeutic proteins and synthetic molecules with emphasis on chromatography, electrophoresis, and/ or mass spectrometry (LC-MS/MS) • Assess a variety of quality attributes of therapeutic proteins with emphasis on chemical modifications including glycosylation, oxidation, deamidation, aspartate isomerization, hydroxylation and others • Work in an analytical group equipped with a variety of chromatographic and electrophoretic systems and mass spectrometry platforms • Communicate (verbal and in written) scientific concepts and results • Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings • Work collaboratively with other scientists on multidisciplinary teams • Work independently in advancing projects and studies within required deadlines • Actively create or contribute to patent and publications • Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen

What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.

Basic Qualifications: Doctorate degree OR Master’s degree and 2 years of Scientific experience OR Bachelor’s degree and 4 years of Scientific experience

Preferred Qualifications: • Ph.D. in Analytical Chemistry, Biochemistry with emphasis in mass spectrometry, chromatography, electrophoresis, or other analytical technique • 2 or more year’s post-PhD experience in the pharmaceutical or biotech industry in process and product development and drug substance and drug product analytical method development • Documented theoretical knowledge and hand-on experience in peptide mapping of proteins, intact and reduced LC-MS analysis for identification and quantification of chemical modifications • Training and experience of operating Thermo Q-Exactive mass spectrometers, Agilent mass spectrometers, and Agilent and Waters HPLCs and UHPLCs and associated data processing software (including empower, chromeleon, biopharmafinder, mass hunter, etc.) • Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects • Knowledge of statistical processing of data, including related software like Excel, Spotfire & JMP • Knowledge of programming using R, Python, C++, or machine learning languages • Experience with automation, robotics, or liquid handlers • Demonstrated proficiency in solving complex problems, ability to work independently, proactively seek outside resources and collaborate, self-starter and team player with strong leadership and decision-making skills capable of providing mentorship to junior staff

What you can expect from us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan • Stock-based long-term incentives • Award-winning time-off plans • Flexible work models where

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