Principal Software Engineer

About this role

Career Category Information Systems Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Principal Software Engineer       What you will do Let’s do this. Let’s change the world. In this vital role you will play a pivotal role in building and scaling our machine learning models from development to production. Your expertise in both machine learning and operations will be essential in creating efficient and reliable ML pipelines. A background in data engineering, including experience with data pipelines and distributed data processing, is a strong plus.  Roles & Responsibilities:    • Lead the  end-to-end design, development, and delivery  of machine learning and Generative AI (GenAI) solutions, from problem framing to production deployment and business impact realization.  

• Act as the  technical owner  for large-scale ML/GenAI initiatives, driving architecture decisions, scalability, reliability, and long-term maintainability.  

• Design and implement advanced  agentic AI systems , including multi-agent architectures, reasoning workflows, tool integration, and autonomous decision-making systems.  

• Define and institutionalize  evaluation, validation, and governance frameworks  for ML/GenAI systems, including model performance, prompt evaluation, safety guardrails, hallucination mitigation, and compliance.  

• Partner directly with  business stakeholders and product leaders  to understand objectives, translate them into AI/ML solutions, and ensure measurable value delivery.  

• Establish and enforce best practices in  MLOps, LLMOps, and DevOps , including CI/CD, monitoring, observability, reproducibility, and cost optimization.  

• Architect and oversee  scalable cloud-based ML/GenAI platforms  leveraging AWS, GCP, or Azure.  

• Drive experimentation strategy, including A/B testing, prompt optimization, and iterative improvement of models and agent workflows.  

• Provide  technical leadership and mentorship  to L4 and L5 engineers, including design reviews, code reviews, and career guidance.  

• Lead cross-functional collaboration across data science, engineering, product, and business teams to deliver integrated AI solutions.  

• Stay at the forefront of advancements in machine learning, Generative AI, and agentic systems, and drive adoption of new technologies and approaches.  

• Design, develop, and implement robust data architectures and platforms to support ML Operation. 

• Ensuring data integrity, accuracy, and consistency through rigorous quality checks and monitoring. 

What we expect of you We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Software Engineer with these qualifications.

Doctorate degree and 2 years of experience OR Master’s degree and 4 years of experience OR Bachelor’s degree and 6 years of  experience OR Associate’s degree and 10 years of  experience OR High school diploma / GED and 12 years of experience

• Deep expertise in machine learning, deep learning, and Generative AI (LLMs, transformers, embeddings, fine-tuning techniques).  

• Proven track record of  leading and delivering production-grade ML/GenAI systems end-to-end  with measurable business impact with strong experience in designing  scalable system architectures  for ML and GenAI, including distributed systems and high-throughput pipelines.  

• Expertise in  MLOps/LLMOps ecosystems  (MLflow, Kubeflow, Airflow, CI/CD, Docker, Kubernetes).  

• Strong system design, architecture, and problem-solving skills with the ability to operate independently and lead large initiatives. 

• Demonstrated proficiency in leveraging cloud platforms (AWS, Azure, GCP) for data engineering solutions. Strong understanding of cloud architecture principles and cost optimization strategies. 

•   Proven ability to mentor and guide junior and mid-level engineers (L4/L5).  

   Good-to-Have Skills:  

Degree in computer science, Statistics, and Data Science preferred. Master’s degree and 6+ years experience Or Bachelor’s degree and 8+ years’ experience  • Cloud Computing certificate preferred 

  Experience with big data ecosystems (Spark, Hadoop) and large-scale data processing.     Strong background in data engineering and building scalable data platforms.   • Advanced proficiency in Python and modern ML/AI frameworks (PyTorch, TensorFlow, Hugging Face, LangChain or similar).  

• Experience designing robust evaluation and validation systems, including automated evals, human-in-the-loop, safety testing, and monitoring frameworks.  

• Extensive experience with RAG architectures, vector databases, and knowledge-grounded systems.  

• Strong understanding of agentic AI frameworks, including orchestration, planning, memory, and tool use.  

  Knowledge of advanced statistical modeling, experimentation design, and causal inference.     Experience with NLP, semantic search, embeddings, and vect

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