Principal Scientist, Lab Platform Disruptive Technologies

About this role

Job Description

We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Our teams combine leading drug discovery capabilities and world-class R&D with the purpose of turning breakthrough science into life-changing medicines.  

Discovery Biologics Disruptive Technologies is seeking a   talented and experienced scientist   to lead the development and deployment of   next-gen   lab-based experimental   technologies   to   enable rapid, data-driven biologics discovery.   This individual will identify and translate emerging, literature-supported technologies into scalable internal capabilities, with a focus on   multiplying   both the scale and speed of quantitative data generation (e.g.,   binding   measurements)   to advance therapeutic programs via   GenAI/ ML-driven discovery and   iterative design-make-test   cycles. The role includes leading a team   with expectation for strong   hands-on contribution to method development, and   will be   accountable for driving measurable program and broader organizational impact.   The role is based out of our Cambridge, MA facility.    

Key Responsibilities  

• Develop   and mature   rapid , quantitative and   high-throughput   lab-based capabilities for   biologics hit identification an d optimization  

• Build and execute   a   technology   platform   roadmap   for arrayed and pooled technologies,   from proof-of-concept through widespread   program adoption  

• Partner effectively with   computational   protein engineering and data science groups   toward   efficient,   integrated   next-gen discovery   workflows  

• Drive capability improvements in   data richness, speed , throughput    

• Lead a   talented   team of   lab-based   scientists  

• As a hands-on individual contributor, realize and maximize   program impact of emerging technologies  

• Collaborate   effectively   across geography and reporting lines   

• Establish   rigorous   benchmarks   (e.g.   throughput,   speed,   reproducibility ,   data quality )   and success criteria  

Qualifications & Experience  

• PhD in Biochemistry, Bioengineering, Chemical Biology, or related field with   7+ years   directly relevant   industry experience ; MS or BS with 12+ years industry experience.  

• Experience developing   large-scale,   high throughput   quantitative   experimental   methods   for biologics discovery  

• Experience   translating published or externally developed methods into   demonstrably   valuable   internal capabilities  

• Proven leadership track record  

Required Skills  

• Demonstrated expertise advancing validated assays and methods toward broad organizational impact  

• Deep hands-on   expertise   in one or more of:   

• Quantitative p ooled   binding   assays   (10k+ sequences)  

• Rapid and high throughput advanced endpoint assays ( e.g.   cell-based function,   stability, localization, etc)   

• Lab-on-chip technologies   and protein arrays  

• M icrofluidics  

• Proven   succes s in   l eadership ,   talent development   and mentorship  

• Strong understanding of biochemistry and biophysical characterization methods  

• Cross-function project leadership track record  

• Strong ability to collaborate across reporting lines, especially with protein engineers and data scientists  

Preferred Skills  

• Strong demonstrated understanding of protein structure-function relationships  

• E xperience applying in   vitro transcription and translation (IVTT)  

• Direct experience in b iophysical   protein characterization  

• Therapeutic high throughput pre-developability and developability assessment  

• Automation and scalable experimental workflows  

• Experience in   workflows leveraging generative AI ML  

Required Skills: Antibody Drug Conjugates (ADC), Biodesign, Detail-Oriented, Emerging Technologies, Ethical Compliance, Gene Cloning, Gene Expression Analysis, Immunochemistry, Leadership Engagement, Mass Spectrometry Analysis, Microscopy Techniques, Project Leadership, Protein Engineering, Protein Interactions, Protein Purifications Preferred Skills:

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.  As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.  For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights EEOC GINA Supplement​

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

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The salary range for this role is $194,100.00 - $305,600.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certificatio

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