Principal Product Technical Leader

About this role

Use Your Power for Purpose At Pfizer, we believe that every role contributes to our mission of improving patients' lives. Whether you are involved in the design and development of manufacturing processes for products or supporting the upkeep of systems, engineering is crucial to ensuring customers and patients receive the medicines they need. By collaborating with our forward-thinking engineering team, you'll play a pivotal role in accelerating the delivery of medicines to the world.

As a Principal Product Technical Leader in Site Technical Services, you will serve as the technical product portfolio owner, setting product philosophy and strategy while acting as the site point of contact within network governance and cross‑functional project teams. You will lead site‑level projects and complex problem solving in collaboration with network stakeholders, providing strong technical leadership and influence. While managing technical projects or issues in a complex environment, you will be able to anticipate and troubleshoot roadblocks and influence teams to achieve site objectives and project goals.

This role is accountable for establishing, maintaining, and continuously improving site-level product technical strategies and product lifecycle management, ensuring site‑ and network‑aligned control strategies, validated‑state compliance, effective risk management, and sustained technical excellence. In addition, you will drive site-level product supply reliability by delivering process robustness improvements, cost‑of‑goods and loss‑reduction initiatives, and hands‑on technical support for troubleshooting, investigations, inspections, and continuous improvement efforts.

What You Will Achieve In this role, you will: • Define and champion portfolio philosophy, product strategy, and long-range technical direction, influencing network standards and industry best practices.

• Represent the site in network governance forums and cross-functional teams, providing leadership, mentoring, and technical development for junior staff.

• Lead complex site and network initiatives, driving project execution, issue resolution, and strategic decision-making with key stakeholders.

• Own site-level product lifecycle management, including control strategy governance, validated-state compliance, risk management, and regulatory strategy alignment across site and network.

• Drive site-level product supply reliability and operational performance through process robustness improvements, cost-of-goods optimization, loss reduction, and manufacturability enhancements.

• Provide technical stewardship for commercial and clinical product portfolios by leading troubleshooting, investigations, inspection readiness, and continuous improvement activities.

Here Is What You Need (Minimum Requirements) • BA/BS with 6+ years of experience or MBA/MS with 5+ years of experience

• Effective written and verbal communication skills

• Strong interpersonal skills and the ability to work collaboratively in a team environment across various business functions

• Experience in project management and leading complex projects

• Ability to develop and manage plans to achieve objectives

Bonus Points If You Have (Preferred Requirements) • 12+ years of relevant pharmaceutical experience

• Experience in problem-solving, negotiations, presentation and working in a matrix based multi-layered organization, including comprehensive understanding of DAMIC (six sigma) tools and practices and a focus on continuous improvement.

• Broad knowledge of technology transfer process and manufacturing for biopharmaceuticals drug substances compounds; Strong technical understanding of pharmaceutical processes and the impact of technical change.

• Demonstrated experience and competence in organizing, planning and problem solving related to biopharmaceuticals drug substances compounds.

• Demonstrated experience on regulatory submission strategy, audit responses and technical discussion with board of health.

PHYSICAL/MENTAL REQUIREMENTS Ability to perform mathematical calculations, scientific computation, complex data analysis, verbal communication, written communication.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Occasional domestic and international travels Occasional off-hour support to address time-sensitive production and business-related issues

Other Job Details: • Last day to Apply: August 28th, 2026

• Work Location Assignment: Hybrid


The annual base salary for this position ranges from $124,400.00 to $207,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.



 Relocation assistance may be available based on business needs and/or eligibility. 
 Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future. 
 Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.

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