Lead Scientist - Directing Cryo-Electron Microscopy and Tomography Center

About this role

St. Jude Children’s Research Hospital is seeking an experienced scientific leader to serve as Lead Scientist - Directing of the Cryo-Electron Microscopy and Tomography (Cryo-EM/Cryo-ET) Center. This position will play a key role in overseeing daily operations of the Center, advancing cryo-EM and cryo-ET workflows, supporting institutional research programs, and leading a team of scientists responsible for user training, instrument operations, and technology development.

The World’s Brightest Minds Always Innovate   At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. 

Environment  

The Cryo - EM/Cryo - ET Center   operates   in close partnership with the Center of Excellence for Structural Cell Biology ( CoE -SCB), which focuses on advanced method development and next-generation workflows in tissue cryo - ET, cryo-volume EM, and correlative imaging. Together, these programs provide investigators with access to   state-of-the-art   instrumentation, computational infrastructure, and scientific   expertise   supporting both routine structural biology and advanced methodological innovation.  

The successful candidate will contribute to the strategic growth of cryo-EM / cryo-ET capabilities at St. Jude and will work closely with faculty, staff scientists, computational teams,   including from   the Center of Excellence for Structural Cell Biology ( CoE -SCB). The position combines scientific leadership, operational oversight, user support, and team management within a highly collaborative and rapidly expanding environment.  

The Cryo - EM/Cryo - ET Center supports a broad range of structural biology and cellular imaging projects spanning pediatric cancer, infectious disease, neuroscience, immunology, and fundamental biology. The Center houses multiple   state-of-the-art   cryo - EM systems including Krios   G3i ,   Krios G4,   Krios   5,   Talos Arctica,   Aquilos   2 cryo-FIB, and advanced computational infrastructure for high-throughput cryo - EM and cryo - ET workflows.  

Key Responsibilities   • Provide scientific and operational leadership for the Cryo - EM/Cryo - ET Center in collaboration with Center leadership and faculty users.    • Supervise and mentor a team of 3   -   4 staff scientists supporting cryo - EM and cryo - ET workflows, instrument operations, user training, and   data handling and processing .    • Oversee day-to-day operation, scheduling,   utilization , and performance of cryo - EM instrumentation, including Krios   G3i ,   Krios G4,   Talos Arctica, Talos L120C, and   Aquilos   2 systems.    • Ensure high-quality user support for single-particle analysis (SPA), cryo-electron tomography (cryo-ET), cryo-FIB milling, cryo-CLEM, and associated workflows.    • Develop and implement training programs for new and advanced users, including microscope operation, sample preparation, data collection, and best-practice workflows.    • Work closely with investigators to design imaging strategies aligned with project goals and scientific   objectives .    • Participate in the development, optimization, and implementation of emerging   C ryo-EM/ C ryo-ET methodologies, automation workflows, and high-throughput approaches.    • Collaborate with computational scientists and HPC teams to support data management, on-the-fly processing, and image analysis workflows.    • Contribute to strategic planning for future instrumentation, workflow development, and facility expansion.    • Maintain and develop standard operating procedures (SOPs), usage policies, safety documentation, and   quality-control   processes.    • Coordinate with vendors, service engineers, and institutional support teams to   maintain   optimal   instrument performance and minimize downtime.    • Foster a collaborative, inclusive, and service-oriented environment that supports scientific excellence across the institution.   

Minimum Education and/or Training: • Bachelor's degree in relevant scientific area is required.

Minimum Experience: • Twelve (12) years of relevant work experience is required with a Bachelor's degree. • Ten (10) years of relevant experience is required with a Master's degree. • Seven (7) years of relevant work experience is required with a PhD.

Preferred Education and Experience: • PhD or equivalent in Structural Biology, Cell Biology, Biophysics, Biochemistry, or a related field.    • Significant hands-on experience with   Cryo-EM/Cryo-ET   workflows.    • Demonstrated   expertise   in operation of high-end cryo - EM instrumentation, including 200 and 300 kV TEM systems.    • Experience with cryo-ET workflows, cryo-FIB milling, cryo-CLEM, or advanced sample preparation methods is   advantageous .    • Familiarity with cryo-EM image-processing software and data-collection platforms such as EPU,   SerialEM , Tomography 5, RELION,   CryoSPARC , Warp, or equivalent tools.   • Strong organizational, communication, and leadership skills.    • Experience supervising or mentoring scientific staff and trainees.    • Ability to work collaboratively in a multidisciplinary research environment.    • Strong commitment to scientific service, training, and user support.   

The World’s Best Stop at Nothing    There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Glassdoor’s “Best Places to Work” list. Actually, there are more than 5,500 reasons. At our world-class pediatric research hospital, every one of our 5,500 professionals shares our commitment to making a difference in the lives of the children we serve. There’s a uni

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