Global Commercial Strategy (GCS): Senior Director, Breast Strategy

About this role

Why Patients Need You

Everything we do, every day, is driven by an unwavering commitment to the patients, healthcare providers, and customers who depend on us. In Global Commercial Strategy (GCS), we translate science of R&D into value for patients and Pfizer - from early development through launch, growth, and LOE lifecycle. GCS serves as the strategic engine and commercial voice across the asset lifecycle - shaping asset positioning and evidence generation, leading global launches, and driving sustained access and brand performance through market and payer insights, broad access, & commercial rigor. We take pride in shaping how innovative medicines reach the people who need them most, and ensuring they are accessible, understood, and valued across every market. Our success is anchored in the following Pfizer Blueprint values: Science, Technology, Transformation and Colleagues. Whether you are defining strategy, managing brands at different lifecycle, or building the capabilities that power our commercial engine, your work directly shapes patient outcomes and the long-term success of Pfizer's portfolio.

Role Summary:

The Senior Director, Breast Strategy is a senior leader within the Oncology vertical, part of the Global Commercial Strategy organization, reporting to the Senior Director Team Leader Breast, GU and Gynecology Strategy Lead, Oncology. This role will lead the development of a holistic breast cancer strategy focused on commercial assessment and portfolio strategy. The role is responsible for developing and maintaining integrated disease-area and portfolio strategies, shaping early commercial assessments, and providing senior commercial leadership to support investment decisions, clinical development choices, lifecycle opportunities, and external innovation assessments across priority assets in breast cancer.

The Oncology portfolio represents a significant opportunity to advance Pfizer's ambition to deliver breakthrough therapies for patients with cancer and related serious conditions. This role will contribute to that ambition by leading breast cancer early commercial and portfolio strategy, shaping disciplined portfolio choices, evidence-informed investment decisions, and early commercial planning across high-value pipeline, lifecycle, and external innovation opportunities. The Senior Director will partner closely with R&D, Medical Affairs, Global Access Strategy & Pricing (GASP), , Global Commercial Analytics (GCA), Competitive Intelligence, Regulatory, Business Development, US, Global and International Commercial / Marketing teams, and other enterprise stakeholders to translate scientific, clinical, market, access, and competitive insights into clear portfolio recommendations. This role is focused on early commercial strategy, disease-area portfolio strategy, and decision support. The Senior Director will help advance disciplined trade-off decisions, long-range portfolio thinking, and AI-enabled ways of working that support patient impact and enterprise value realization for the Oncology portfolio.

Responsibilities:

Breast Cancer Portfolio Strategy and Long-Range Planning: ·       Lead development and ongoing refinement of integrated breast cancer commercial and portfolio strategies, spanning early pipeline assets, lifecycle opportunities, external innovation, and emerging disease-area opportunities. ·       Establish a holistic view of near-, mid-, and long-term opportunities, including disease-area priorities, asset-level implications, portfolio sequencing, and strategic trade-offs. ·       Synthesize scientific, clinical, commercial, access, competitive, and patient insights to inform portfolio priorities and differentiated value creation opportunities. ·       Translate portfolio strategy into clear recommendations, implications, and decision materials for leadership, governance forums, and cross-functional teams. ·       Monitor shifts in the breast scientific and competitive landscape to identify emerging trends, risks, development opportunities, and potential implications for Pfizer Oncology strategy.

Early Commercial Assessment and Asset Strategy: ·       Lead and guide early commercial assessments for breast cancer pipeline assets, indications, mechanisms, disease-area opportunities, and lifecycle programs. ·       Oversee development and refinement of product concepts, target product profile input, positioning hypotheses, market archetypes, and commercial opportunity assessments. ·       Translate unmet need, standard of care, competitive dynamics, biomarker and treatment pathway considerations, patient/HCP insights, and access requirements into differentiated commercial hypotheses. ·       Provide senior commercial input to clinical development, evidence generation, indication sequencing, lifecycle strategy, and launch-readiness discussions in partnership with cross-functional colleagues. ·       Identify key value drivers, risks, uncertainties, and evidence needs that may influence future launch potential, asset differentiation, and portfolio value.

Business Development and External Innovation Support: ·       Serve as a senior commercial strategy partner for Business Development and external innovation opportunities relevant to breast cancer oncology priorities. ·       Lead or oversee commercial opportunity assessments, valuation inputs, market-sizing assumptions, competitive scenarios, and strategic fit evaluations for potential internal or external assets. ·       Partner with Business Development, R&D, GCA, GASP, Competitive Intelligence, Medical Affairs, and Regulatory colleagues to pressure-test assumptions and identify key decision points. ·       Represent the breast cancer commercial perspective in discussions related to external innovation, asset valuations, launch strategies, and long-term value creation. ·       Develop clear, executive-ready materials that communicate commercial opportunity, strategic rationale, risks, uncertainties, and p

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