Executive Director, Scientific & Medical Excellence

About this role

Mavericks Wanted

When was the last time you achieved the impossible? If that thought feels overwhelming, you might want to pause here, but if it sparks excitement...read on   In 2015, we pioneered a “moneyball for biotech” approach, pooling projects and promising early-stage research from academia together under one financial umbrella to reduce risk and unleash innovation. This model allows science and small teams of experts to lead the way. We build bridges to groundbreaking advancements in rare disease, and develop life-changing medicines for patients with unmet needs as fast as humanly possible.    Together we define white space, push boundaries, and empower people to solve problems. If you're someone who defies convention, join us and work alongside some of the most respected minds in the industry. Together, we'll ask "why not?" and help reengineer the future of biopharma. At BridgeBio, we value curiosity and experimentation—including the ethical & thoughtful use of AI to improve clarity, speed, and quality of work.

What You'll Do

The Executive Director, Scientific & Medical Excellence is a senior leadership role within Medical Affairs, accountable for the cross-cutting scientific capabilities and programs that serve BridgeBio’s portfolio. This leader will own evidence generation planning, the investigator-sponsored trial (IST) and sponsored research portfolio, Medical Information, expanded access / compassionate use programs, and the integration of artificial intelligence into Medical Affairs ways of working—while driving global planning and alignment across affiliates and functions.

This individual will build and scale the operating model, governance, and standards that allow Medical Affairs to act with scientific rigor, speed, and compliance. The role requires deep expertise in rare disease, the maturity to lead in a matrixed, fast-paced environment, and the vision to modernize how a medical organization generates and exchanges scientific evidence. The role partners closely with Clinical Development, Regulatory, Commercial, Market Access, HEOR, Patient Advocacy, and Field Medical.

Responsibilities

Evidence Generation Planning

• Lead the development of the integrated evidence generation plan, in partnership with HEOR, aligned to overarching medical and asset strategy and informed by clearly prioritized scientific and stakeholder evidence gaps.

• Coordinate the planning of real-world evidence (RWE), registries, natural history studies, database analyses, and Phase 4 / post-marketing studies in partnership with Clinical Development, HEOR, and Biostatistics.

• Ensure evidence plans support regulatory interactions, value demonstration, payer engagement, and HTA requirements, and that data are disseminated through a coordinated publication strategy.

Investigator-Sponsored Trials (IST) & Sponsored Research Partnerships

• Own the strategy, governance, and end-to-end operations of the investigator-sponsored trial (IST) program, including the review committee, scientific prioritization, and funding decisions aligned to medical strategy and evidence gaps.

• Develop and manage sponsored research collaborations and external research partnerships with academic centers, consortia, and cooperative groups.

• Establish transparent processes for proposal intake, contracting, milestone tracking, publication expectations, and compliant oversight of supported research.

• Partner with Legal, Compliance, Finance, and Regulatory to ensure all externally sponsored research meets internal standards and applicable regulations.

Medical Information

• In partnership with the Bridge Bio MI Lead, manage affiliate Medical Information function, including strategy, content, and operations for responding to unsolicited requests from healthcare professionals, patients, and other stakeholders.

• Oversee development and scientific governance of standard response documents, FAQs, and the medical information content library, ensuring accuracy, balance, and compliance.

• In partnership with Central Med Info, manage call center / vendor operations, escalation pathways, and service-level standards for medical inquiry handling.

Expanded Access / Compassionate Use Programs

• Develop, implement, and manage expanded access / compassionate use (early access, named-patient, and managed access) programs in alignment with medical, regulatory, and ethical standards.

• Establish governance, eligibility criteria, request-handling workflows, and supply coordination, balancing patient need with program integrity and compliance.

• Partner with Regulatory, Clinical, Supply Chain, Legal, and Patient Advocacy across regions to ensure consistent, equitable, and compliant access processes.

Technology & Innovation in Medical Affairs

• Define and drive the Medical Affairs AI strategy—identifying, piloting, and scaling AI and advanced analytics use cases across medical information, evidence synthesis, content generation, insights, and operations.

• Partner with Data Science, IT, Legal, and Compliance to establish responsible-use, governance, validation, and data-privacy guardrails for AI tools in a regulated environment.

• Champion change management and capability building so teams adopt new tools effectively, with measurable impact on quality, speed, and decision-making.

Global Medical Planning & Alignment

• Drive global medical planning and alignment, harmonizing strategy, standards, and ways of working across affiliates, regions, and partners.

• Build the operating model, governance forums, and shared tools/metrics that ensure consistency while enabling regional execution.

• Serve as a connective leader across Medical Affairs sub-functions and cross-functional partners to ensure coordinated, on-strategy delivery.

Leadership & Compliance

• Coach and develop a high-performing team; foster a culture of integrity, scientific rigor, and operational excellence.

• Collaboratively develop and help execute medical plans

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