Executive Director, Digital Enablement

About this role

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

The Executive Director, Digital Enablement (DE) is a newly created role with a mandate to ensure that digital and AI capabilities give Vaxcyte better leverage across every launch function. Initially focused on the commercial launch of VAX-31 for the adult indication, this role will lead the build of the digital infrastructure, AI capabilities, and commercial technology roadmap from the ground up for Vaxcyte as a first-time launching company.

The Executive Director, DE serves as an enabler across functions, designing systems and capabilities so that Marketing, Sales, Medical Affairs, Market Access, Commercial Operations (e.g. 3PL, Distribution, Customer Service, etc), Data and Analytics and any other commercial teams have less friction, better intelligence, and more leverage than the competition. The DE will work collaboratively with these partners to determine business needs and recommend/build system capabilities across the organization

This role sits within the Commercial organization and works in close partnership with the IT Commercial Lead (ITCL) in the IT function, who will own implementation, data security, and technical management. This role will own strategy through execution and ensure our launch functions are fully enabled.

This role also supports the digital, data, and AI needs of Medical Affairs as one of several functions it enables, while respecting the independence of Medical Affairs in setting its own scientific strategy, content, and engagement priorities. All Medical Affairs enablement operates within the company’s compliance framework, preserving the separation of promotional and non-promotional activity and the independence of scientific engagement.

Essential Functions:

Commercial Digital Strategy and Product Roadmap

• Develop a phased commercial digital vision for the US adult launch covering pre-launch, launch, and growth phases, with defined milestones and measurable outcomes at each stage.

• Own and maintain a commercial product roadmap that treats each digital capability — CRM, marketing technology, field enablement, analytics, AI tools — as a discrete product with a use case, a user, a success metric, and a release schedule.

• Map the end-to-end commercial experience from the account manager and field rep perspective through to provider and executive touchpoints, identifying where digital creates genuine leverage and where added complexity should be avoided.

• Define and prioritize AI use cases for field force effectiveness, marketing operations, customer segmentation, content production, and performance analytics — sequenced by business impact and data readiness.

• Ensure that no technology decision precedes a defined commercial use case; architecture follows strategy and vendor selection follows requirements.

Cross-Functional Leadership and Business Translation

• Serve as the commercial voice in all digital and technology planning conversations, ensuring that field, marketing, Medical Affairs, Market Access, and commercial operations priorities drive decisions.

• Translate commercial strategy into language that IT, vendors, and data teams can build from; translate technical constraints and trade-offs into language that commercial leaders can act on.

• Partner with Marketing to build the martech stack, performance marketing capability, and content infrastructure, and to streamline MLR review so approved content reaches the field faster. Identify where AI raises the ceiling — content generated and adapted at scale, and review workflows that move faster without lowering the bar.

• Partner with Sales and Field Force Excellence to equip the field with CRM, call planning, territory management, and mobile tools that make reps more effective in front of customers. Identify where AI raises the ceiling — next-best-action guidance, pre-call intelligence, and automation that returns selling time to reps.

• Partner with Medical Affairs to build capabilities to enable and enhance Medical Affairs activities, including digital engagement, scientific exchange tools, congress engagement platforms, and KOL mapping

• Partner with Market Access and Commercial Operations to stand up contract management, chargeback and revenue management, and Sunshine Act compliance workflows that hold up under launch volume. Identify where AI raises the ceiling — anomaly detection, scenario modelling, and monitoring that flags issues before they surface.

• Serve as the primary liaison to the IT Commercial Lead (ITCL), ensuring technology implementation aligns with commercial strategy.

AI-First Capability Building

• The goal of this role is to examine every commercial launch capability area — marketing, field, Medical Aff

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