Clinical Research Project Manager

About this role

Job Details The Clinical Research Project Manager independently leads and manages clinical trials from study start-up through closeout, ensuring adherence to protocol requirements, institutional standards, and applicable regulatory guidelines. This role provides operational oversight of research activities, including feasibility planning, subject recruitment and retention, data and specimen management, and regulatory compliance. The manager may supervise and develop research staff, drives process improvements, and contributes to the development of standard operating procedures. Additionally, the position represents the organization in internal and external forums and serves as a subject matter expert, providing strategic guidance and consultation at the departmental or institutional level.

Job Description In this role, the Clinical Research Project Manager will provide operational leadership for an enterprise-wide clinical implementation project focused on hypertension management in primary care and support investigators and projects across the Primary Care Research Center. In collaboration with Center leadership, principal investigators, and project sponsors, the manager will translate strategic priorities into operational plans and coordinate stakeholders, resources, milestones, deliverables, budgets, reporting, and evaluation activities to support successful project execution.

The hypertension management project, funded by the PCORI Health System Implementation Initiative, will implement a team-based, comprehensive care model to address care gaps related to this condition across the Jefferson primary care network. It will evaluate the implementation, as well as effectiveness, of the program on patient-level blood pressures outcomes and patient-reported health distress and self-efficacy. The work is informed by findings from PCORI-funded comparative clinical effectiveness research on clinic- and telehealth-based models of hypertension care.  

The Jefferson Primary Care Research Center is a university-wide structure that supports investigators and leaders from across multiple disciplines who conduct research within the primary care environment. The Center’s core research areas include primary care innovation, cardiovascular health, lifestyle medicine and weight management, geriatrics, cancer prevention, integrated behavioral health, and women’s health.

The Clinical Research Project Manager independently leads and manages clinical trials from study start-up through closeout, ensuring adherence to protocol requirements, institutional standards, and applicable regulatory guidelines. This role provides operational oversight of research activities, including feasibility planning, subject recruitment and retention, data and specimen management, and regulatory compliance. The manager may supervise and develop research staff, drives process improvements, and contributes to the development of standard operating procedures. Additionally, the position represents the organization in internal and external forums and serves as a subject matter expert, providing strategic guidance and consultation at the departmental or institutional level.

Job Duties • Leads the operational planning and execution of an enterprise-wide clinical implementation project focused on hypertension management in primary care, coordinating activities across participating practices, clinical teams, project leadership, and other Jefferson Health stakeholders. • Supports principal investigators and Center leadership in planning and managing grant-funded research, implementation initiatives, and other projects within the Primary Care Research Center, including defining project requirements, timelines, milestones, deliverables, resource needs, and measures of success. • Proactively identifies and addresses project risks, implementation barriers, scope changes, and emerging challenges; facilitates communication and alignment among investigators, project teams, administrative partners, external collaborators, and other stakeholders. • Monitors project deliverables, reporting requirements, budgets, expenditures, and evaluation activities in collaboration with project leadership and post-award teams, and supports the use of findings to inform program improvement and operational decision-making. • Independently oversees and executes all phases of clinical trials from start-up to closeout, including feasibility assessments, protocol coordination (screening, recruiting, enrolling, consenting), data and biological specimen management, and preparation for monitoring visits, ensuring compliance with Good Clinical Practice (GCP) and all applicable regulations. • May supervise, train, and mentor research staff, ensuring proper conduct of clinical trials, adherence to protocols, and consistent application of regulatory and institutional standards. • Prepares, reviews, and submits regulatory and IRB documentation in a timely manner, maintains accurate study records and subject logs, tracks study finances, and performs quality control assessments to ensure integrity, accuracy, and audit readiness of clinical trial data. • Leads or supports research operations within a division or department, contributes to and implements standard operating procedures, participates in leadership initiatives, and represents the organization internally and externally while providing expert consultation on clinical research processes and compliance.

Minimum Qualifications • Bachelor’s degree and 5 years of clinical research experience  or Master’s Degree and 3 year clinical research experience.

Additional Qualifications • Oversees the completion of all necessary regulatory preparations prior to sponsor visits (e.g., monitoring and auditing visits, site activation visits). Ensures that any regulatory action items resulting from a sponsor visit are completed in a timely and efficient manner. • Ensures that regulatory document version control is maintained, and t

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